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專(zhuān)家人才
- 姓名： 林首恒
- 性別： 男
- 職稱(chēng)： 副研究員
- 學(xué)歷： 博士
- 電話(huà)：
- 傳真：
- 電子郵件: lin_shouheng@gibh.ac.cn
- 通訊地址 廣州市黃埔區開(kāi)源大道190號
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2021.03至今 中國科學(xué)院廣州生物醫藥與健康研究院 副研究員
2018.08-2021.02 廣州醫科大學(xué)附屬第三醫院 博士后
2013.09-2018.07 中國科學(xué)院大學(xué) 博士
2009.09-2013.07 華南農業(yè)大學(xué) 學(xué)士
簡(jiǎn)歷：
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1.肺癌轉移的機制；
2.靶向腫瘤微環(huán)境的免疫治療。
研究領(lǐng)域：
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1. 國家自然科學(xué)基金青年項目，82003054，MDSC-腫瘤細胞正向反饋促進(jìn)非小細胞肺癌轉移的機制研究，2021.1-2023-12，項目負責人。
2. 廣東省基礎與應用基礎研究基金項目，2019A1515110084，MDSC來(lái)源的CCL11促進(jìn)NSCLC的間充質(zhì)樣轉變和轉移的機制研究，2020.1-2021.12，項目負責人。
3. 第64批中國博士后科學(xué)基金面上資助，2018M640771，地貧小鼠模型的建立及基因編輯治療地貧的臨床前評估，2018.11-2021.2，項目負責人。
承擔科研項目情況：
社會(huì )任職：
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廣東省科技進(jìn)步二等獎 “人源化小鼠及其臨床前評估平臺的建立及應用“（2019, 7/10）
獲獎及榮譽(yù)：
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1. Lin, Shouheng#; Zhang, Xuchao#; Huang, Guohua#; Cheng, Lin#; Lv, Jiang; Zheng, Diwei; Lin, Simiao; Wang, Suna; Wu, Qiting; Long, Youguo; Li, Baiheng; Wei, Wei; Liu, Pentao; Pei, Duanqing; Li, Yangqiu; Wen, Zhesheng; Cui, Shuzhong; Li, Peng; Sun, Xiaofang*; Wu, Yilong*; Yao, Yao*; Myeloid-derived suppressor cells promote lung cancer metastasis by CCL11 to activate ERK and AKT signaling and induce epithelial-mesenchymal transition in tumor cell,Oncogene,2021 Feb;40(8):1476-1489.
2. Lin, Shouheng; Cheng, Lin; Ye, Wei; Li, Shanglin; Zheng, Diwei; Qin, Le; Wu, Qiting; Long, Youguo; Lin, Simiao; Wang, Suna; Huang, Guohua; Li, Peng; Yao, Yao*; Sun, Xiaofang*; Chimeric CTLA4-CD28-CD3z T Cells Potentiate Antitumor Activity Against CD80/CD86-Positive B Cell Malignancies, Frontiers in Immunology, 2021 Apr 2;12:642528.
3. Lin, Shouheng#; Huang, Guohua#; Cheng, Lin#; Li, Zhen; Xiao, Yiren; Deng, Qiuhua; Jiang, Yuchuan; Li, Baiheng; Lin, Simiao; Wang, Suna; Wu, Qiting; Yao, Huihui; Cao, Su; Li, Yang; Liu, Pentao; Wei, Wei; Pei, Duanqing; Yao, Yao; Wen, Zhesheng; Zhang, Xuchao; Wu, Yilong; Zhang, Zhenfeng; Cui, Shuzhong; Sun, Xiaofang; Qian, Xueming*; Li, Peng*; Establishment of peripheral blood mononuclear cell-derived humanized lung cancer mouse models for studying efficacy of PD-L1/PD-1 targeted immunotherapy, mAbs, 2018, 10(8): 1301-1311.
4. Lin, Shouheng#; Huang, Guohua#; Xiao, Yiren; Sun, Wei; Jiang, Yuchuan; Deng, Qiuhua; Peng, Muyun; Wei, Xinru; Ye, Wei; Li, Baiheng; Lin, Simiao; Wang, Suna; Wu, Qiting; Liang, Qiubin; Li, Yangqiu; Zhang, Xuchao; Wu, Yilong; Liu, Pentao; Pei, Duanqing; Yu, Fenglei; Wen, Zhesheng; Yao, Yao; Wu, Donghai*; Li, Peng*; CD215 Myeloid Cells Respond to Interleukin 15 Stimulation and Promote Tumor Progression, Frontiers in Immunology, 2017, 8: 1713.
5. Lai, Yunxin; Wei, Xinru; Lin, Shouheng; Qin, Le; Cheng, Lin; Li, Peng*; Current status and perspectives of patient-derived xenograft models in cancer research, Journal of Hematology & Oncology, 2017, 10(1): 106.
6. Xiong, Zeyu; Xie, Yingjun; Yang, Yi; Xue, Yanting; Wang, Ding; Lin, Shouheng; Chen, Diyu; Lu, Dian; He, Lina; Song, Bing; Yang, Yinghong; Sun, Xiaofang*；Efficient gene correction of an aberrant splice site in beta-thalassaemia iPSCs by CRISPR/Cas9 and single-strand oligodeoxynucleotides，Journal of Cellular and Molecular Medicine, 2019, 23(12): 8046-8057.
7.Chang, Yanqun; Lin, Shouheng; Li, Yongsheng*; Liu, Song; Ma, Tianbao; Wei, Wei； Umbilical cord blood CD34(+) cells administration improved neurobehavioral status and alleviated brain injury in a mouse model of cerebral palsy，Childs Nerv Syst, 2021, 37(7): 2197-2205.
8.Jiang, Zhiwu; Wu, Di; Lin, Shouheng; Li, Peng*； CD34 and CD38 are prognostic biomarkers for acute B lymphoblastic leukemia，Biomark Res, 2016, 4: 23.
9. Lin, Shouheng; Zhao, Ruocong; Xiao, Yiren; Li, Peng*；Mechanisms determining the fate of hematopoietic stem cells，Stem Cell Investig, 2015, 2: 10.