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               首頁(yè) >> 資源庫 >> 中文 >> 專(zhuān)家人才
            
                
            

                
            專(zhuān)家人才
            

                
            
                    
            
                        
              
                            
            • 姓名： 潘光錦
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            • 性別： 男
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            • 職稱(chēng)： 研究員
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            • 學(xué)歷： 博士
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            • 電話(huà)： 
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            • 傳真： 
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            • 電子郵件: pan_guangjin@gibh.ac.cn
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            • 通訊地址 廣州市開(kāi)源大道190號
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              簡(jiǎn)歷：
              
                            
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              　　1999年至2002年：山東醫學(xué)科學(xué)院，醫學(xué)碩士。
              

              　　2002年至2005年：清華大學(xué)醫學(xué)院，理學(xué)博士。
              

              　　2005年至2010年：美國威斯康星大學(xué)-麥迪遜(University of Wisconsin-Madison)，博士后、助理研究員。
              

              　　2010年至今：  中國科學(xué)院廣州生物醫藥與健康研究院，研究員。
              

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              研究領(lǐng)域：
              
                            
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              　　1、人胚胎干（ES）細胞多能性及自我更新的分子生物學(xué)調控。借助人胚胎干細胞為模型，研究不同生物學(xué)層面包括，信號傳導，轉錄因子，表觀(guān)遺傳學(xué)（Signaling Pathway, Transcription Factor and Epigetics）等對于人ES 細胞多能性和分化的調控。并探討這些不同層面之間的相互作用及調控機制。
              

              　　2、 人誘導性多能干（iPS）細胞的形成及臨床應用的可行性實(shí)驗室研究。
              

              

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              承擔科研項目情況：
              
                            
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              社會(huì )任職：
              
                            
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              獲獎及榮譽(yù)：
              
                            
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              代表論著(zhù)：
              
                            
            • 在Nature Methods、Cell Stem Cell、Cell、Stem Cell Reports、 FASEB J、JBC、Cell Res、Stem Cell Reports、Biomaterails等雜志發(fā)表論文30余篇，共被引用2000多次。主要工作是：將人尿液細胞轉變?yōu)榉钦系纳窠?jīng)干細胞；首次發(fā)現人胚胎干細胞具有特殊的組蛋白甲基化調控模式；在國內率先開(kāi)展胚胎干細胞轉錄因子（Oct4, Sox2, Nanog）對多能性的調控研究，首次發(fā)現干細胞中轉錄因子間的負反饋調控機制。
              

              （*為通訊作者）
              

              1.  Wang, L., Wang, L., Huang, W., Su, H., Xue, Y., et al, Pan, G*., and Pei, D*. Generation of integration-free neural progenitor cells from cells in human urine. Nature Methods 10, 84-89 (2013) 
              

              2.  Ma, N., Shan, Y., Liao, B., Kong, G., Wang, C., et al., Chen, N*., and Pan, G*.  Factor-induced Reprogramming and Zinc Finger Nuclease-aided Gene Targeting Cause Different Genome Instability in β-Thalassemia Induced Pluripotent Stem Cells (iPSCs). Journal of Biological Chemistry 290, 12079-12089 (2015)
              

              3.   Ma N, Liao B, Zhang H, Wang L, Shan Y, et al, Pan, G*. Transcription activator-like effector nuclease (TALEN)-mediated gene correction in integration-free β-thalassemia induced pluripotent stem cells. Journal of Biological Chemistry 288,34671-34679（2013） 
              

              4.   Wang, L., Li, X., Huang, W., Zhou, T., Wang, H., Lin, A., Hutchins, A. P., Su, Z., Chen, Q., Pei, D., and Pan, G*.  TGFβ signaling regulates the choice between pluripotent and neural fates during reprogramming of human urine derived cells. Scientific Reports 6, 22484 (2016)
              

              5.   Li D, Wang L, Hou J, et al. Optimized Approaches for Generation of Integration-free iPSCs from Human Urine-Derived Cells with Small Molecules and Autologous Feeder. Stem Cell Reports, 6(5): 717-728 (2016)
              

              6.   Wang H, Hu L, Liu C, et al. 5-HT2 receptors mediate functional modulation of GABAa receptors and inhibitory synaptic transmissions in human iPS-derived neurons. Scientific Reports, 6: 20033 (2016)
              

              7.   Xue, Y., Cai, X., Wang, L., Liao, B., Zhang, H., et al, Pan, G*. Generating a Non-Integrating Human Induced Pluripotent Stem Cell Bank from Urine-Derived Cells. PLoS ONE 8, e70573 (2013) 
              

              8.   Liu, J., Wang, L., Su, Z., Wu, W., Cai, X., Li, D., Hou, J., Pei, D., and Pan, G*. A reciprocal antagonism between miR-376c and TGF-b signaling regulates neural differentiation of human pluripotent stem cells. Faseb Journal 28, 4642-4656. (2014)
              

              9.  Huang, K., Jia, J., Wu, C., Yao, M., Li, M., et al, Pan, G*., and Yao, H*. Ribosomal RNA Gene Transcription Mediated by the Master Genome Regulator Protein CCCTC-binding Factor (CTCF) Is Negatively Regulated by the Condensin Complex. Journal of Biological Chemistry 288, 26067-26077 (2013) 
              

              10.  Huang K, Liu P, Li X, Chen S, Wang L, et al, Pan, G*. Neural progenitor cells from human induced pluripotent stem cells generated less autogenous immune response. SCIENCE CHINA-Life Sciences 57,162-170（2014）
              

              11.   Liu, P., Chen, S., Li, X., Qin, L., Huang, K., et al, Pan, G*., Cai, J*., and Pei, D*. Low Immunogenicity of Neural Progenitor Cells Differentiated from Induced Pluripotent Stem Cells Derived from Less Immunogenic Somatic Cells.PLoS ONE 8, e69617 (2013) 
              

              12.  Pan, G., and Pei, D*. Order from Chaos: Single Cell Reprogramming in Two Phases. Cell Stem Cell 11, 445-447.（2012）
              

              13.  Pan, G., Wang, Tao., Yao, H., Pei D.* Somatic cell reprogramming for regenerative medicine: SCNT vs. iPS cells. BIOESSAYS 34 472-476.（2012）
              

              14.  Wang, T., Chen, K., et al., Esteban, Miguel A., Pan, G., and Pei, D*.The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner. Cell Stem Cell 9 575-587 (2011) 
              

              15.   Yu, P.,Pan, G.,Yu, J., and Thomson, James A. FGF2 Sustains NANOG and Switches the Outcome of BMP4-Induced Human Embryonic Stem Cell Differentiation.Cell Stem Cell8, 326-334 (2011) 
              

              16.  Xu, N., Papagiannakopoulos, T., Pan, G., Thomson, J. A., and Kosik, K. S. MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 137, 647-658 (2009)
              

              17. Xu, R.-H., Sampsell-Barron, T. L., Gu, F., Root, S., Peck, R. M., Pan, G., et al., Thomson, J. A. NANOG Is a Direct Target of TGF[beta]/Activin-Mediated SMAD Signaling in Human ESCs. Cell Stem Cell 3, 196-206 (2008) 
              

              18.  Pan, G., Tian, S., Nie, J., Yang, C., et al., Thomson, J. A. Whole-Genome Analysis of Histone H3 Lysine 4 and Lysine 27 Methylation in Human Embryonic Stem Cells. Cell Stem Cell 1, 299-312(2007) (被引334次)
              

              19.  Pan, G*., and Thomson, J. A. NANOG and transcriptional networks in embryonic stem cell pluripotency.Cell Research 17, 42-49(2007) (被引195次)
              

              20.  Pan, G., Li, J., Zhou, Y., Zheng, H., and Pei, D. A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. FASEB J 20, 1730-1732(2006) (被引114次)
              

              21  Pan, G., and Pei, D. The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus. Journal of Biological Chemistry 280, 1401-1407 (2005) 
              

              22.  Pan, G., Qin, B., Liu, N., Scholer, H. R., and Pei, D. Identification of a nuclear localization signal in OCT4 and generation of a dominant negative mutant by its ablation. Journal of Biological Chemistry 279, 37013-37020 (2004)
              

              23.  Pan, G., and Pei, D. Identification of two distinct transactivation domains in the pluripotency sustaining factor NANOG. Cell Research 13, 499-502 (2003)
              

              24.   Pan, G., Chang, Z. Y., Scholer, H. R., and Pei, D. Stem cell pluripotency and transcription factor OCT4. Cell Research 12, 321-329 (2002) (被引141次)
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